Directing lung endoderm differentiation in pluripotent stem cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22482501.
- Also identified by DOI 10.1016/j.stem.2012.03.013 and PMC identifier 3366272.
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Abstract
The lung is composed of numerous epithelial lineages that arise from the anterior foregut endoderm. This review discusses how insights into the signaling mechanisms that regulate lung endoderm specification and subsequent differentiation have recently been exploited to direct differentiation of hESCs/iPSCs into expandable lung progenitors.
Medical subject headings
- Cell Differentiation
- Endoderm
- Lung
- Pluripotent Stem Cells
- Signal Transduction