Proliferation and metabolism: it's as easy as APC.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22482721.
- Also identified by DOI 10.1016/j.cmet.2012.03.012.
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Abstract
Proliferating cells must generate both ATP and biosynthetic precursors for macromolecular synthesis. While proliferative signals have long been known to regulate metabolism, Garedew et al. now demonstrate that the proliferation apparatus itself, in the form of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C), directly controls mitochondrial biogenesis, morphology, and respiratory activity.