A comprehensive computational model of facilitated diffusion in prokaryotes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22492644.
- Also identified by DOI 10.1093/bioinformatics/bts178 and PMC identifier 3356843.
- Licence recorded as CC BY-NC.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Gene activity is mediated by site-specific transcription factors (TFs). Their binding to defined regions in the genome determines the rate at which their target genes are transcribed. We present a comprehensive computational model of the search process of TF for their genomic target site(s). The computational model considers: the DNA sequence, various TF species and the interaction of the individual molecules with the DNA or between themselves. We also demonstrate a systematic approach how to parametrize the system using available experimental data.
Medical subject headings
- Computer Simulation
- DNA
- Escherichia coli
- Lac Repressors