Parvovirus 4 infection and clinical outcome in high-risk populations.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 22492853.
- Also identified by DOI 10.1093/infdis/jis291 and PMC identifier 3357136.
- Licence recorded as CC BY-NC.
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Abstract
Parvovirus 4 (PARV4) is a DNA virus frequently associated with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections, but its clinical significance is unknown. We studied the prevalence of PARV4 antibodies in 2 cohorts of HIV- and HCV-infected individuals (n = 469) and the correlations with disease status. We found that PARV4 infection frequently occurred in individuals exposed to bloodborne viruses (95% in HCV-HIV coinfected intravenous drug users [IDUs]). There were no correlations between PARV4 serostatus and HCV outcomes. There was, however, a significant association with early HIV-related symptoms, although because this was tightly linked to both HCV status and clinical group (IDU), the specific role of PARV4 is not yet clear.
Medical subject headings
- Antibodies, Viral
- HIV Infections
- Hepatitis C
- Parvoviridae Infections