Kim-1/Tim-1 and immune cells: shifting sands.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 22499138.
- Also identified by DOI 10.1038/ki.2012.11 and PMC identifier 3339439.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been controversial. In the presence of very high epithelial cell expression, understanding the influence of immune cell Kim-1/Tim-1 expression in kidney injury relies on a better definition of its functional significance in immune cells and better characterization of antibodies used to probe function.
Medical subject headings
- CD4-Positive T-Lymphocytes
- Glomerulonephritis
- Immunity, Cellular
- Kidney
- Lymphocyte Activation
- Membrane Proteins