Can we cure HIV-1-associated nephropathy in transgenic mice?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22499139.
- Also identified by DOI 10.1038/ki.2012.13 and PMC identifier 3334344.
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Abstract
HIV-1-associated nephropathy (HIVAN) is a rapidly progressive form of focal segmental glomerulosclerosis. HIV transgenic mice can develop a HIVAN-like renal disease. Zhong et al. show that the oral administration of a cyclic nucleotide phosphodiesterase 4 inhibitor and a retinoic acid receptor-α agonist can prevent the development of HIVAN in transgenic mice, acting through a cAMP-dependent mechanism that is independent of HIV-1 genes. These findings suggest that endogenous host factors play a critical role in HIVAN.
Medical subject headings
- AIDS-Associated Nephropathy
- Aminopyridines
- Benzamides
- Benzoates
- HIV Infections
- HIV-1
- Kidney Tubules
- Phosphodiesterase 4 Inhibitors
- Renal Insufficiency
- Tetrahydronaphthalenes