Breathe in and straighten your back: hypoxia, notch, and scoliosis.
editorial · Level V
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- Record sourced from PubMed, PMID 22500793.
- Also identified by DOI 10.1016/j.cell.2012.03.024.
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Abstract
In this issue of Cell, Sparrow et al. propose a new mechanism for sporadically occurring congenital scoliosis in which Notch signaling and hypoxia converge in the embryo on somite patterning via the segmentation clock. This interaction between hypoxia and a predisposed genetic background might underlie other birth defects with incomplete penetrance.