Sgs1--the maestro of recombination.
basic_science · Level V
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- Record sourced from PubMed, PMID 22500794.
- Also identified by DOI 10.1016/j.cell.2012.03.020.
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Abstract
The Sgs1 DNA helicase and its mammalian homolog BLM control crossover formation in mitotic cells. Zakharyevich et al. and De Muyt et al. now uncover a key role for Sgs1 in meiotic crossover regulation, which in turn reveals a joint molecule resolution pathway that produces the majority of crossovers in budding yeast.