Connective tissue diseases. Unravelling aetiology in male SLE--the X chromosome dose effect.
Where this comes from
- Record sourced from PubMed, PMID 22508431.
- Also identified by DOI 10.1038/nrrheum.2012.44.
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Abstract
New evidence suggesting an X chromosome effect underlies the development and progression of male systemic lupus erythematosus comes from a study of sex chromosome aneuploidy in men with this disease. The description of a number of immunoregulatory mechanisms encoded on the X chromosome support this hypothesis; however, further studies are warranted.
Medical subject headings
- Chromosomes, Human, X
- Gene Dosage
- Lupus Erythematosus, Systemic