Nodal expression and detection in cancer: experience and challenges.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22508696.
- Also identified by DOI 10.1158/0008-5472.CAN-11-3419 and PMC identifier 3334352.
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Abstract
Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.
Medical subject headings
- Neoplasms
- Nodal Protein