Nanoparticle-assisted stimulated-emission-depletion nanoscopy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22530602.
- Also identified by DOI 10.1021/nn301082g.
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Abstract
We show that metal nanoparticles can be used to improve the performance of super-resolution fluorescence nanoscopes based on stimulated-emission-depletion (STED). Compared with a standard STED nanoscope, we show theoretically a resolution improvement by more than an order of magnitude, or equivalently, depletion intensity reductions by more than 2 orders of magnitude and an even stronger photostabilization. Our scheme may allow improvement of existing STED nanoscopes and assist in the development of low-power, low-cost nanoscopes. This has the potential to increase the availability of STED nanoscopes and lead to a significant expansion of our understanding of biological and biochemical phenomena occurring on the nanoscale.
Medical subject headings
- Image Interpretation, Computer-Assisted
- Microscopy, Fluorescence
- Models, Theoretical
- Molecular Imaging
- Nanoparticles
- Nanotechnology