Is hepatitis C virus carcinogenic?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22537433.
- Also identified by DOI 10.1053/j.gastro.2012.01.045 and PMC identifier 4422399.
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Abstract
Although infection with hepatitis C virus (HCV) has become a leading cause of hepatocellular carcinoma, the mechanisms by which it results in carcinogenesis remain a subject of debate. Here, we explore the possibility that HCV replication impairs cellular DNA damage responses, thereby promoting instability of the infected host cell genome, and that HCV exerts a direct cancer-promoting effect in addition to eliciting immune-mediated inflammation and apoptosis of hepatocytes contributing to hepatocellular carcinogenesis.
Medical subject headings
- Carcinogens
- Carcinoma, Hepatocellular
- Hepacivirus
- Hepatitis C
- Liver Neoplasms