Dissecting spindle architecture with a laser.
basic_science · Level V
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- Record sourced from PubMed, PMID 22541422.
- Also identified by DOI 10.1016/j.cell.2012.04.006.
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Abstract
Microtubules in spindles are too dense to resolve by light microscopy, even with super-resolution methods. Using a new method based on laser-ablation techniques, Brugués et al. present the first quantitative characterization of the vertebrate meiotic spindle and propose an assembly mechanism for building this architecture.