Dialing down SUN1 for laminopathies.
editorial · Level V
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- Record sourced from PubMed, PMID 22541423.
- Also identified by DOI 10.1016/j.cell.2012.04.003.
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Abstract
Laminopathies, caused by mutations in A-type nuclear lamins, encompass a range of diseases, including forms of progeria and muscular dystrophy. In this issue, Chen et al. provide evidence that elevated expression of the nuclear inner membrane protein SUN1 drives pathology in multiple laminopathies.