Programmed anti-inflammatory macrophages protect against AKI and promote repair through trophic actions.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 22543903.
- Also identified by DOI 10.1038/ki.2012.9.
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Abstract
Because pharmacological interventions for the treatment of acute kidney injury (AKI) have remained ineffective, cell-based therapies have been developed. Marrow stromal cells have been found to be safe and potentially effective in study subjects. Jung et al. demonstrate that macrophages made to overexpress anti-inflammatory interleukin-10 protect rats with AKI through iron-mediated upregulation of lipocalin-2 and its receptors, eliciting both anti-inflammatory and proliferative responses. These data further advance our understanding of cell-based therapies for AKI.
Medical subject headings
- Acute Kidney Injury
- Adoptive Transfer
- Interleukin-10
- Ischemia
- Kidney
- Lipocalins
- Macrophages
- Reperfusion Injury