Colony-stimulating factors.

Wakefield, P E; James, W D; Samlaska, C P; Meltzer, M S · J Am Acad Dermatol · 1990

review · Level V

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Abstract

Recombinant hematopoietic colony-stimulating factors have profound effects on developing and mature granulocytes, macrophages, and lymphocytes. Use of these agents for treatment of disease may result in a variety of adverse cutaneous reactions. The recent discovery of colony-stimulating factor production by keratinocytes and dermal cells suggests that these agents may also be significant in cutaneous homeostasis and in the pathogenesis of cutaneous diseases.

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