Pluronic F108 coating decreases the lung fibrosis potential of multiwall carbon nanotubes by reducing lysosomal injury.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22546002.
- Also identified by DOI 10.1021/nl300895y and PMC identifier 4143198.
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Abstract
We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.
Medical subject headings
- Coated Materials, Biocompatible
- Lysosomes
- Nanotubes, Carbon
- Poloxamer
- Pulmonary Fibrosis