Contactless conductivity biosensor in microchip containing folic acid as bioreceptor.

Lima, Renato S; Piazzetta, Maria H O; Gobbi, Angelo L; Rodrigues-Filho, Ubirajara P; Nascente, Pedro A P; Coltro, Wendell K T; Carrilho, Emanuel · Lab Chip · 2012

basic_science · Level V

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Abstract

We report a glass/PDMS-based microfluidic biosensor that integrates contactless conductivity transduction and folic acid, a target for tumor biomarker, as a bioreceptor. The device presents relevant advantages such as direct determination--dismiss the use of redox mediators as in faradaic electrochemical techniques--and the absence of the known drawbacks related to the electrode-solution interface. Characterizations of the functionalization processes and chemical sensor are described in this communication.

Medical subject headings