BEAMing up personalized medicine: mutation detection in blood.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 22550168.
- Also identified by DOI 10.1158/1078-0432.CCR-12-0871 and PMC identifier 3377838.
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Abstract
BEAMing is a feasible, accurate, and sensitive method for detection of PIK3CA mutations in circulating tumor DNA in blood. Mutation status of PIK3CA may change between primary tumor and recurrence. The results suggest a new approach for noninvasive determination of current mutation status in patients with metastatic disease.
Medical subject headings
- Breast Neoplasms
- DNA, Neoplasm
- Phosphatidylinositol 3-Kinases