TH17 deficiency in human disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22554706.
- Also identified by DOI 10.1016/j.jaci.2012.03.034 and PMC identifier 3388506.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The differentiation of naive T cells into distinct subsets of effector T cells is critical for effective immunity against a wide variety of infectious agents in the environment. Activation of innate immune responses by Candida species through pattern-recognition receptors directs the subsequent development of naive T cells into T(H)17 cells, which are essential for effective mucosal immunity against fungi. Thorough analyses of cohorts of patients with unusual susceptibility to chronic mucocutaneous candidiasis resulting from T(H)17 deficiency have confirmed the role of T(H)17 cells and T(H)17 cytokines in human host defense against Candida species and have provided valuable insights into the complex process of T(H)17 cell development.
Medical subject headings
- Candidiasis, Chronic Mucocutaneous
- Immunity, Innate
- Th17 Cells