Restoring cell polarity: an HSC fountain of youth.
editorial · Level V
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- Record sourced from PubMed, PMID 22560067.
- Also identified by DOI 10.1016/j.stem.2012.04.015.
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Abstract
Until recently, aging was viewed as a fixed and irreversible process. However, in this issue of Cell Stem Cell, Florian et al. (2012) reveal a link between increased activity of the RhoGTPase Cdc42, hematopoietic stem cell polarity, and aging that can be regulated by pharmacological inhibition of Cdc42.