Grounded: transcriptional pausing in naive mESCs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22560069.
- Also identified by DOI 10.1016/j.stem.2012.04.016.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Growing mouse pluripotent stem cells in defined media with signaling inhibitors establishes a naive ground state different from that of cells grown in serum. Recently in Cell, Marks et al. (2012) reported differences in the transcriptional and epigenomic landscapes of naive and serum-exposed mouse stem cells that improve our understanding of the pluripotent ground state.