NuRD and pluripotency: a complex balancing act.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22560073.
- Also identified by DOI 10.1016/j.stem.2012.04.011 and PMC identifier 3348611.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Embryonic stem cells (ESCs) are defined by two essential features--pluripotency and self-renewal--whose balance requires the concerted action of signal transduction pathways, transcription factor networks, and epigenetic regulators. Recent findings have implicated the NuRD chromatin remodeling complex in the sophisticated choreography of ESC regulatory pathways.
Medical subject headings
- Chromatin Assembly and Disassembly
- Embryonic Stem Cells
- Mi-2 Nucleosome Remodeling and Deacetylase Complex
- Pluripotent Stem Cells