Enhancement of anti-inflammatory drug activity by multivalent adamantane-based dendrons.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22560196.
- Also identified by DOI 10.1016/j.biomaterials.2012.03.072.
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Abstract
We have developed a straightforward method to prepare 1(st) and 2(nd) generation adamantane-based dendrons, previously called HYDRAmers, bearing at the periphery the anti-inflammatory drug, ibuprofen. The multivalency effect on the drug activity was studied, demonstrating that our multivalent ibuprofen-dendron conjugates exert an enhanced anti-inflammatory activity compared to free ibuprofen, in vitro. These results provide insights into the effect of HYDRAmer multivalency on biological interactions for therapeutic applications.
Medical subject headings
- Anti-Inflammatory Agents
- Cell Survival
- Dendrimers
- Ibuprofen
- Macrophages