Fortifying the link between SIRT1, resveratrol, and mitochondrial function.
Where this comes from
- Record sourced from PubMed, PMID 22560207.
- Also identified by DOI 10.1016/j.cmet.2012.04.016 and PMC identifier 3491563.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The molecular mechanisms behind the health benefits of resveratrol remain enigmatic and controversial. In this issue of Cell Metabolism, Price et al. establish a clear chemical-genetic connection between SIRT1 and resveratrol, providing strong evidence that SIRT1 is critical for resveratrol to stimulate mitochondrial biogenesis and a switch toward oxidative muscle fibers (Price et al., 2012).