Muscling in on PGC-1α for improved quality of life in ALS.
basic_science · Level V
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- Record sourced from PubMed, PMID 22560208.
- Also identified by DOI 10.1016/j.cmet.2012.04.015.
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Abstract
Impaired activity of peroxisome proliferator-activated receptor (PPAR)-γ coactivator (PGC)-1α has been implicated in the pathophysiology of several neurodegenerative disorders. In this issue, Da Cruz et al. (2012) show improved muscle function, but not survival, with increased PGC-1α activity in muscle in a mouse model of amyotrophic lateral sclerosis.