A ceramide-centric view of insulin resistance.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22560211.
- Also identified by DOI 10.1016/j.cmet.2012.04.002.
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Abstract
The recent implementation of genomic and lipidomic approaches has produced a large body of evidence implicating the sphingolipid ceramide in a diverse range of physiological processes and as a critical modulator of cellular stress. In this review, we discuss from a historical perspective the most important discoveries produced over the last decade supporting a role for ceramide and its metabolites in the pathogenesis of insulin resistance and other obesity-associated metabolic diseases. Moreover, we describe how a ceramide-centric view of insulin resistance might be reconciled in the context of other prominent models of nutrient-induced insulin resistance.
Medical subject headings
- Ceramides
- Insulin
- Insulin Resistance
- Sphingolipids