Interplay between lipids and branched-chain amino acids in development of insulin resistance.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22560213.
- Also identified by DOI 10.1016/j.cmet.2012.01.024 and PMC identifier 3695706.
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Abstract
Fatty acids (FA) and FA-derived metabolites have long been implicated in the development of insulin resistance and type 2 diabetes. Surprisingly, application of metabolomics technologies has revealed that branched-chain amino acids (BCAA) and related metabolites are more strongly associated with insulin resistance than many common lipid species. Moreover, the BCAA-related signature is predictive of incident diabetes and intervention outcomes and uniquely responsive to therapeutic interventions. Nevertheless, in animal feeding studies, BCAA supplementation requires the background of a high-fat diet to promote insulin resistance. This Perspective develops a model to explain how lipids and BCAA may synergize to promote metabolic diseases.
Medical subject headings
- Amino Acids, Branched-Chain
- Insulin Resistance
- Lipid Metabolism