King of hearts: a splicing factor rules cardiac proteins.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 22561820.
- Also identified by DOI 10.1038/nm.2762.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766-773).
Medical subject headings
- Cardiomyopathy, Dilated
- Muscle Proteins
- Protein Kinases
- RNA Splicing
- RNA-Binding Proteins