BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data.
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- Record sourced from PubMed, PMID 22563071.
- Also identified by DOI 10.1093/bioinformatics/bts272 and PMC identifier 3389765.
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Abstract
Despite recent progress, computational tools that identify gene fusions from next-generation whole transcriptome sequencing data are often limited in accuracy and scalability. Here, we present a software package, BreakFusion that combines the strength of reference alignment followed by read-pair analysis and de novo assembly to achieve a good balance in sensitivity, specificity and computational efficiency. http://bioinformatics.mdanderson.org/main/BreakFusion
Medical subject headings
- Computational Biology
- Sequence Analysis, RNA
- Software
- Transcriptome