The impact of genomics on pediatric research and medicine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22566424.
- Also identified by DOI 10.1542/peds.2011-3636 and PMC identifier 3362911.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this review, we discuss some of the most recent developments in genomics research and their relevance to the field of pediatrics. In particular, we examine 3 major approaches that are being used to identify genetic correlates of disease: genome-wide association studies, copy number variation studies, and next-generation sequencing. In the past few years, these approaches have yielded major insights into the causes and pathophysiology of a wide range of diseases but are also constrained by certain limitations. This review provides an overview of the genomic landscape in complex pediatric disorders and sets the stage for translating new discoveries into clinical practice, the future of genomic medicine.
Medical subject headings
- Biomedical Research
- Genomics
- Pediatrics