The manipulation of natural killer cells to target tumor sites using magnetic nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22575830.
- Also identified by DOI 10.1016/j.biomaterials.2012.04.041 and PMC identifier 3571620.
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Abstract
The present work demonstrates that Cy5.5 conjugated Fe(3)O(4)/SiO(2) core/shell nanoparticles could allow us to control movement of human natural killer cells (NK-92MI) by an external magnetic field. Required concentration of the nanoparticles for the cell manipulation is as low as ~20 μg Fe/mL. However, the relative ratio of the nanoparticles loaded NK-92MI cells infiltrated into the target tumor site is enhanced by 17-fold by applying magnetic field and their killing activity is still maintained as same as the NK-92MI cells without the nanoparticles. This approach allows us to open alternative clinical treatment with reduced toxicity of the nanoparticles and enhanced infiltration of immunology to the target site.
Medical subject headings
- Immunomagnetic Separation
- Killer Cells, Natural
- Neoplasms, Experimental