EGFR in limbo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22579278.
- Also identified by DOI 10.1016/j.cell.2012.04.015.
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Abstract
The epidermal growth factor receptor (EGFR) is normally activated by ligand-induced dimerization. Oncogenic mutations in EGFR promote activation in a largely ligand-independent manner. Shan et al. uncover a partially disordered state of EGFR kinase, providing evidence that oncogenic mutations counteract this intrinsic structural instability to promote dimerization and aberrant activation.