Sibling rivalry among paralogs promotes evolution of the human brain.
editorial · Level V
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- Record sourced from PubMed, PMID 22579279.
- Also identified by DOI 10.1016/j.cell.2012.04.020 and PMC identifier 3477634.
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Abstract
Geneticists have long sought to identify the genetic changes that made us human, but pinpointing the functionally relevant changes has been challenging. Two papers in this issue suggest that partial duplication of SRGAP2, producing an incomplete protein that antagonizes the original, contributed to human brain evolution.