Receptor specificity defines algogenic properties of propofol and fospropofol.
basic_science · Level V
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- Record sourced from PubMed, PMID 22584560.
- Also identified by PMC identifier 3433588.
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Abstract
Propofol-evoked injection site pain is not observed with fospropofol. We hypothesized that unlike propofol, fospropofol does not activate the irritant receptor, transient receptor potential 1 (TRPA1). We tested the hypothesis using electrophysiology and behavioral studies. Our data demonstrate that propofol (100 μM) evokes an inward current only in TRPA1-expressing neurons. However, fospropofol (100 μM and 1 mM) is unable to evoke depolarizing currents in either TRPA1-positive or TRPA1-negative neurons. Both propofol and fospropofol produced general anesthesia. The lack of algogenic activity in fospropofol is most likely the result of its inability to activate TRPA1 on nociceptors.
Medical subject headings
- Hypnotics and Sedatives
- Pain
- Propofol
- TRPC Cation Channels