Disease specific biomarkers of abdominal aortic aneurysms detected by surface enhanced laser desorption ionization time of flight mass spectrometry.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 22595147.
- Also identified by DOI 10.1016/j.ejvs.2012.04.018.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Biomarkers have the potential to improve the clinical management of patients with AAA. A prospective, proteomics discovery study was undertaken to compare patients with AAA (n = 20) to matched screened controls (n = 19) for plasma protein expression. Surface-Enhanced-Laser-Desorption-Ionization Time of Flight Mass Spectrometry (SELDI ToF MS) coupled with Artificial Neural Networks (ANN) analysis identified six protein related diagnostic biomarker ions with a combined AUC of 0.89. This study discovered a signature plasma protein profile for patients with AAA and demonstrated that mass spectrometric based research for disease specific biomarker of AAA is feasible.
Medical subject headings
- Aortic Aneurysm, Abdominal
- Biomarkers
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization