Stiff-man syndrome: a GABAergic autoimmune disorder with autoantigenic heterogeneity.
case_report · Level V
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Abstract
Autoantibodies that reacted with cell bodies and axon terminals of gamma-aminobutyric acid (GABA)ergic neurons were present in the serum and cerebrospinal fluid in a patient with stiff-man syndrome with type I diabetes. Immunoblot experiments using this patient's serum and cerebrospinal fluid did not corroborate an earlier observation that these autoantibodies are directed against the GABAergic cytosolic enzyme, L-glutamic acid decarboxylase. While L-glutamic acid decarboxylase autoantibodies may be associated with this syndrome, they do not appear to be easily demonstrated.
Medical subject headings
- Autoantibodies
- Autoimmune Diseases
- Brain Diseases
- Glutamate Decarboxylase