Skull vault destruction after rhinocerebral mucormycosis.

Abstract

Mucormycosis is a relatively rare form of fungal infection that can be rapidly progressive. Clinical presentation depends on the anatomic area of involvement; however, the commonest form is that of rhinocerebral. This is the first case of extensive and progressive destruction of the skull vault despite antifungal therapy. The patient required aggressive surgical resection to arrest the disease progression and complex reconstruction using a custom made titanium cranioplasty. This report highlights the need for early aggressive resection for cases of mucormycosis infection where there is bony involvement.