Nanoporous peptide particles for encapsulating and releasing neurotrophic factors in an animal model of neurodegeneration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22610659.
- Also identified by DOI 10.1002/adma.201200634 and PMC identifier 3543853.
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Abstract
Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.
Medical subject headings
- Brain-Derived Neurotrophic Factor
- Drug Carriers
- Hearing Loss, Sensorineural
- Nanoparticles
- Peptides