The number of p16INK4a positive cells in human skin reflects biological age.
Where this comes from
- Record sourced from PubMed, PMID 22612594.
- Also identified by DOI 10.1111/j.1474-9726.2012.00837.x and PMC identifier 3539756.
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Abstract
Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence. We observed that a younger biological age associates with lower levels of p16INK4a positive cells in human skin.
Medical subject headings
- Aging
- Cyclin-Dependent Kinase Inhibitor p16
- Skin