Microfibers fabricated by non-covalent assembly of peptide and DNA for viral vector encapsulation and cancer therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22628070.
- Also identified by DOI 10.1002/adma.201201145.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Self-assembled amphiphilic peptide units and supercoiled, circular double-stranded plasmid DNA are used as building blocks to form peptide/DNA fibers for virus encapsulation. Since the fiber formation process takes place under ambient conditions and is aqueous-based without the use of denaturing organic solvents, the bioactivity of viruses is well preserved.
Medical subject headings
- DNA
- Drug Carriers
- Genetic Therapy
- Genetic Vectors
- Glioma
- Microtechnology
- Peptides