Biased DNA segregation during stem cell division.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22628572.
- Also identified by DOI 10.1161/CIRCRESAHA.112.268961 and PMC identifier 3407569.
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Abstract
Adult skeletal muscle stem cells are a heterogeneous cell population characterized by a small subset of undifferentiated cells that express at high level the paired/homeodomain gene <i>Pax7</i>. This category of satellite cells divides predominantly by asymmetric chromatid segregation generating a daughter cell that carries the mother DNA and retains stem cell property, and a daughter cell that inherits the newly-synthesized DNA and acquires the myocyte lineage.