Feeling the squeeze: live-cell extrusion limits cell density in epithelia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22632965.
- Also identified by DOI 10.1016/j.cell.2012.05.006 and PMC identifier 4752205.
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Abstract
Tissues develop in confined volumes that can impose mechanical constraints on their growth, but it is unclear how cells respond to these limits to regulate tissue size and shape. Two papers show that overcrowding and cell deformation lead to the shedding of live cells to maintain homeostasis in epithelial cell sheets.