Rheumatoid arthritis. Evidence for a genetic component to disease severity in RA.
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- Record sourced from PubMed, PMID 22647779.
- Also identified by DOI 10.1038/nrrheum.2012.74 and PMC identifier 3668790.
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Abstract
Rheumatoid arthritis (RA) is partly heritable; genetic and serological markers are known to confer risk of developing pathology. But given clinical heterogeneity in RA, can we predict who will develop severe disease? Substantial heritability of erosive progression rates has now been identified, but better prognostic biomarkers remain wanting.
Medical subject headings
- Arthritis, Rheumatoid
- Genetic Predisposition to Disease
- Quantitative Trait, Heritable
- Severity of Illness Index