Near-infrared light-responsive intracellular drug and siRNA release using au nanoensembles with oligonucleotide-capped silica shell.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22648937.
- Also identified by DOI 10.1002/adma.201200785.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Taking advantage of the character of Au nanorods (NRs) to absorb NIR light, a NIR-responsive oligonucleotide-gated ensemble is developed to perform intracellular drug delivery. Using an oligonucleotide bio-gate enables siRNA release into cells for translational regulation as well as cytotoxicity in anti-cancer drug delivery.
Medical subject headings
- Gold
- Infrared Rays
- Nanotubes
- Oligonucleotides
- RNA, Small Interfering
- Silicon Dioxide