Peroxiredoxin sets the brain on fire after stroke.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 22673994.
- Also identified by DOI 10.1038/nm.2797 and PMC identifier 3955950.
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Abstract
How blood-borne inflammatory cells cause tissue damage in the brain after ischemic stroke remains elusive. Peroxiredoxins, cytosolic antioxidant proteins vital for redox balance, are released extracellularly from ischemic cells, acting as potent ‘danger signals’ that activate macrophages and lead to a harmful cytokine response, a new study shows. The findings unveil a new culprit in the delayed phase of ischemic injury and suggest new therapeutic approaches (pages 911–917).
Medical subject headings
- Brain
- Brain Ischemia
- Peroxiredoxins
- Stroke