MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22678362.
- Also identified by DOI 10.1126/science.1219723 and PMC identifier 3420340.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Instability of the nuclear genome is a hallmark of cancer and aging. MMS19 protein has been linked to maintenance of genomic integrity, but the molecular basis of this connection is unknown. Here, we identify MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery. MMS19 functions as part of the CIA targeting complex that specifically interacts with and facilitates iron-sulfur cluster insertion into apoproteins involved in methionine biosynthesis, DNA replication, DNA repair, and telomere maintenance. MMS19 thus serves as an adapter between early-acting CIA components and a subset of cellular iron-sulfur proteins. The function of MMS19 in the maturation of crucial components of DNA metabolism may explain the sensitivity of MMS19 mutants to DNA damage and the presence of extended telomeres.
Medical subject headings
- DNA
- DNA, Fungal
- Genomic Instability
- Iron-Sulfur Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription Factors