HOT models in flux: mitochondrial glucose oxidation fuels glioblastoma growth.
basic_science · Level V
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- Record sourced from PubMed, PMID 22682216.
- Also identified by DOI 10.1016/j.cmet.2012.05.004 and PMC identifier 3376384.
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Abstract
Cancer cells in culture obtain ATP and biosynthetic precursors primarily by aerobic glycolysis, not by mitochondrial glucose oxidation. In this issue of Cell Metabolism, Marin-Valencia et al. (2012) demonstrate that glioblastoma, an aggressive and, in culture, highly glycolytic cancer, primarily uses glucose oxidation to meet energetic and biosynthetic demands in vivo.