REV-ERBs: more than the sum of the individual parts.
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- Record sourced from PubMed, PMID 22682217.
- Also identified by DOI 10.1016/j.cmet.2012.05.006.
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Abstract
REV-ERB nuclear receptors have been believed to stabilize the circadian clock machinery through an accessory but dispensable feedback loop. Recent work now challenges this assumption by demonstrating that REV-ERBs are essential core clock components, in addition to serving as pivotal regulators of rhythmic metabolism.