Field cancerization: something new under the sun.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 22682238.
- Also identified by DOI 10.1016/j.cell.2012.05.013.
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Abstract
Mutations in keratinocyte and melanocyte precursors that are caused by extensive sun exposure are well-established contributors to skin cancer. Now Hu et al. provide evidence that the sun's harmful rays may also cause tumor-promoting epigenetic modifications in dermal fibroblasts, highlighting further the importance of tumor-stroma interactions in cancer.